Her victim in the quarter-final was Venus Williams. Kim Clijsters of Belgium continues to dominate the hardcourt summer.Roger Federer loses his first set of the tournament against Nicolas Kiefer of Germany.Andre Agassi is stretched to five sets against Belgian Xavier Malisse.It was only the second time (after their second round meeting at the 1998 Australian Open) that the sisters met before the quarter-finals of a Grand Slam tournament. Tenth seed Venus Williams beats her little sister and 2005 Australian Open champion Serena Williams to reach the quarter-finals, (7-6, 6-2).James Blake declared the player of the day for the 2nd time in the tournament. 2 seed - and one of the candidates to win the title - Rafael Nadal of Spain. Indian teen sensation Sania Mirza became the first Indian woman to reach the 4th round of any Grand Slam.2003 Champion Andy Roddick lost to Gilles Müller 7-6, 7-6, 7-6.He was beaten by wildcard Brian Baker in straight sets: 7-6(9), 6-2, 6-4. Ninth-seeded Gastón Gaudio ( 2004 French Open champion) also lost in the first round.It marked the fourth time a women's defending champion was ousted in her first match. Defending champion Svetlana Kuznetsova of Russia became the first defending women's champion to lose in the first round during the Open Era.

Vera Zvonareva → replaced by María Sánchez Lorenzo.

Michaëlla Krajicek → replaced by Ekaterina Bychkova.

Elena Bovina → replaced by Emmanuelle Gagliardi.

Joachim Johansson → replaced by Karol Kučera.

Guillermo Cañas → replaced by Dick Norman.

Top 5 seeds (mixed doubles) Mixed doubles Top 5 seeds (women's doubles) Women's doubles Top 5 seeds (men's doubles) Men's doubles More information on the top 32 seeds here. * Fifth seed Marat Safin (Russia) withdrew before the start of the tournament. Seeds Top 10 seeds (singles) Men's singles Nikola Fraňková / Alisa Kleybanova defeating Alexa Glatch / Vania King, 7–5, 7–6(3) Main article: 2005 US Open – Girls' doubles This was the first time that future US Open (Tennis) champion Andy Murray was featured in the tournament. It was the first of three US Open titles for Clijsters, also winning in 20. Kim Clijsters won her first Grand Slam title after four previous Grand Slam final losses. Svetlana Kuznetsova was unsuccessful in her title defence, losing in the first round against compatriot Ekaterina Bychkova. Roger Federer was successful in defending his 2004 title, defeating Andre Agassi in the final. It was, however, featured during the 2011 final between Novak Djokovic and Rafael Nadal, the 2016 final between Djokovic and Stan Wawrinka, and the 2021 final between Djokovic and Daniil Medvedev, respectively. The '9/11/01' sign to remember the 9/11 attacks was not featured on the court. It was held between Augand September 11, 2005. The 2005 US Open was the fourth and final Grand Slam of 2005. USTA Billie Jean King National Tennis Center

Andre agassi us open 2006